173897-44-4

Basic information

• Product Name: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
• Synonyms: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride;Y 39983, 2 HCl salt;Y-33075 (dihydrochloride);Y 39983 2HCL;Y-33075 2HCl
• CAS NO: 173897-44-4
• Molecular Formula: C16H18Cl2N4O
• Molecular Weight: 353.24632
• Mol File: 173897-44-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in DMSO
• CAS DataBase Reference: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride(173897-44-4)
• EPA Substance Registry System: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride(173897-44-4)

Safety Data

• Hazardous Substances Data: 173897-44-4(Hazardous Substances Data)

Usage

Uses

Y-39983 Hydrochloride contain Rho kinase inhibitory activity.

Biological Activity

y-39983 dihydrochloride is a novel and selective inhibitor of rock family with ic50 value of 3.6nm for rock [1].y-39983 dihydrochloride has shown a selective inhibitor of rho-associated coiled coil-forming protein kinase( rock ) with ic50 values of 3.6nm, 0.42μm and 0.81μm for rock, pkc and camkii, respectively [1]. apart from these, y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. in addition, y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. moreover, y-39983 lowered the intraocular pressure ( iop) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].

references

[1] tokushige h1, inatani m, nemoto s, sakaki h, katayama k, uehata m, tanihara h. effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. invest ophthalmol vis sci. 2007 jul;48(7):3216-22.[2] watabe h1, abe s, yoshitomi t. effects of rho-associated protein kinase inhibitors y-27632 and y-39983 on isolated rabbit ciliary arteries. jpn j ophthalmol. 2011 jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. epub 2011 jun 11.

Upstream product

• 173897-93-3 (R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-benzyloxycarbonylaminoethyl)benzamide 
• 173897-73-9 (R)-4-(1-benzyloxycarbonylaminoethyl)benzoic acid chloride 
• 173898-15-2 (R)-(+)-4-(1-benzyloxycarbonylaminoethyl)-benzoic acid 

Relevant articles and documents

VISUAL FUNCTION DISORDER IMPROVING AGENTS

The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo?2,3-büpyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent