17391-18-3 Usage
Description
Corynoxine B is an oxindole alkaloid that is derived from Uncaria rhynchophylla (Miq.) Jacks, commonly known as Gouteng in Chinese. It has been identified for its Beclin-1-dependent autophagy-inducing properties, which make it a compound of interest in various research and therapeutic applications.
Uses
Used in Pharmaceutical Applications:
Corynoxine B is used as a Beclin-1-dependent autophagy inducer for its potential role in the development of therapeutic strategies targeting conditions where autophagy plays a crucial role. Its ability to induce autophagy may offer benefits in treating diseases associated with impaired cellular recycling and waste removal processes.
Used in Research Applications:
In the field of research, Corynoxine B serves as a valuable tool for studying the mechanisms of autophagy and its regulation. It can be used to investigate the Beclin-1-dependent pathway and its implications in cellular homeostasis and response to stress.
Used in Drug Development:
Corynoxine B may be utilized in the development of new drugs targeting autophagy-related diseases. Its properties as an autophagy inducer could be harnessed to create novel therapeutics for conditions where enhancing autophagy could be beneficial, such as neurodegenerative diseases or cancer.
Used in Traditional Medicine:
As a component of Uncaria rhynchophylla, Corynoxine B may also be used in traditional Chinese medicine, where the plant is already known for its various health benefits. It could be incorporated into formulations aimed at promoting overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 17391-18-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,9 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17391-18:
(7*1)+(6*7)+(5*3)+(4*9)+(3*1)+(2*1)+(1*8)=113
113 % 10 = 3
So 17391-18-3 is a valid CAS Registry Number.
17391-18-3Relevant articles and documents
Ban et al.
, p. 2113 (1972)
Shellard et al.
, p. 2505,2510 (1971)
Total synthesis of the spirocyclic oxindole alkaloids corynoxine, corynoxine B, corynoxeine, and rhynchophylline
Wanner, Martin J.,Ingemann, Steen,Van Maarseveen, Jan H.,Hiemstra, Henk
, p. 1100 - 1106 (2013/03/29)
Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N-2-butenylated 2-hydroxytryptamine, which underwent a base-mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C-ring. The second key step was a Pd-catalysed cyclisation of an α-keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N-substituent) to form the D-ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time. Racemic total syntheses of the four title spirocyclic oxindole alkaloids are reported starting from 4-hydroxytryptamine. The key steps were a base-mediated Mannich spirocyclisation to form the C-ring, and a Pd-catalysed cyclisation of a keto ester enolate onto an allylic carbonate to form the D-ring. Thus, convenient syntheses of the alkaloids were achieved, for three of them for the first time. Copyright
