17391-47-8Relevant academic research and scientific papers
Diacetone-glucose architecture as a chirality template. Part 9. Enantioselectiye synthesis of (R)-mevalonolactone and (R)-[2H9]mevalonolactone on carbohydrate template
Kishida, Masashi,Yamauchi, Noriaki,Sawada, Keiju,Ohashi, Yuji,Eguchi, Tadashi,Kakinuma, Katsumi
, p. 891 - 895 (2007/10/03)
A highly enantioselective synthetic methodology for (R)-mevalonolactone has been developed based upon the chirality-transcription approach using a chiral template, diacetone-D-glucos-3-ulose 2. (R)-Mevalonolactone 1a is prepared from ketone 2 in 5 steps in 11% overall yield. This methodology is further applied to the synthesis of fully deuteriated (R)-[2H9]mevalonolactone 1b starting from ketone 2 and methyl [2H7]senecioate 7.
