Gambogenic acid, a natural xanthone compound, is derived from the roots of Garcinia hanburyi and other plants. It is known for its anti-inflammatory and anti-tumor properties and has been utilized in traditional Chinese medicine. Gambogenic acid demonstrates cytotoxicity against various cancer cell lines and induces apoptosis in cancer cells by disrupting their cell cycle and promoting DNA damage. It also exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines and inhibiting the activation of inflammatory signaling pathways. With its potential as a therapeutic agent for cancer and inflammation, gambogenic acid is a promising candidate for further research and development.
173932-75-7
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Basic information
- Product Name: Gambogenic acid
- Synonyms: Gambogenic acid;(2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid
- CAS NO:173932-75-7
- Molecular Formula: C38H46O8
- Molecular Weight: 630.77
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 818.6±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.27±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 4.58±0.36(Predicted)
- CAS DataBase Reference: Gambogenic acid(CAS DataBase Reference)
- NIST Chemistry Reference: Gambogenic acid(173932-75-7)
- EPA Substance Registry System: Gambogenic acid(173932-75-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 173932-75-7(Hazardous Substances Data)
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173932-75-7 Usage
Uses
Used in Pharmaceutical Industry:Gambogenic acid is used as an anticancer agent for its cytotoxic effects on various cancer cell lines, including breast, lung, and liver cancer. It induces apoptosis and inhibits cancer cell growth by disrupting the cell cycle and promoting DNA damage.
Used in Anti-inflammatory Applications:
Gambogenic acid is used as an anti-inflammatory agent to suppress the production of pro-inflammatory cytokines and inhibit the activation of inflammatory signaling pathways, making it a potential therapeutic agent for inflammatory conditions.
Used in Drug Development:
Gambogenic acid is used in the development of novel drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles can be employed as carriers for gambogenic acid delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 173932-75-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,9,3 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.Calculate Digit Verification of CAS Registry Number 173932-75:
(8*1)+(7*7)+(6*3)+(5*9)+(4*3)+(3*2)+(2*7)+(1*5)=157
157 % 10 = 7
So 173932-75-7 is a valid CAS Registry Number.
173932-75-7Upstream product
173932-75-7Downstream Products
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Gambogenic acid
