173934-26-4Relevant articles and documents
Asymmetric Synthesis of Homocitric Acid Lactone
Nickerson, Leslie A.,Huynh, Valerie,Balmond, Edward I.,Cramer, Stephen P.,Shaw, Jared T.
, p. 11404 - 11408 (2016/11/28)
A short, diastereoselective synthesis of homocitric acid lactone is described. The key step is a bioinspired aldol addition to set the stereogenic center in an intermediate that requires only modest oxidation state manipulation to complete the synthesis. This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced by heavier nuclei at nearly every position.
An improved synthesis of trisodium (U)-homocitrate from citric acid
Prokop,Milewska
experimental part, p. 1317 - 1322 (2010/07/05)
A method of synthesis of trisodium (R)-homocitrate starting from citric acid is reported. The procedure affords the final product of high optical purity with satisfactory yield.
A facile method for synthesis of (R)-(-)- and (S)-(+)-homocitric acid lactones and related α-hydroxy dicarboxylic acids from D- or L-malic acid
Xu, Peng-Fei,Matsumoto, Tsuyoshi,Ohki, Yasuhiro,Tatsumi, Kazuyuki
, p. 3815 - 3818 (2007/10/03)
We report here a simple and convenient route for the stereoselective synthesis of (R)-(-)- and (S)-(+)-homocitric acid lactones, which play very important roles in biochemistry. The method involves only three steps, starting from the readily available met