17397-85-2Relevant articles and documents
Isocoumarin derivative as well as preparation method and medical application thereof
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Paragraph 0249-0253; 0262-0265, (2020/03/17)
The invention belongs to the technical field of chemical medicines, and relates to an isocoumarin compound of general formula (I) and a preparation method and medical application, of the isocoumarin compound in preparation of medicines for treating and mo
Ruthenium-NHC-Diamine Catalyzed Enantioselective Hydrogenation of Isocoumarins
Li, Wei,Wiesenfeldt, Mario P.,Glorius, Frank
, p. 2585 - 2588 (2017/03/08)
A novel and practical chiral ruthenium-NHC-diamine system is disclosed for the enantioselective hydrogenation of isocoumarins, which provides a new concept to apply (chiral) NHC ligands in asymmetric catalysis. A variety of optically active 3-substituted 3,4-dihydroisocoumarins were obtained in excellent enantioselectivities (up to 99% ee). Moreover, this methodology was utilized in the synthesis of O-methylmellein, mellein, and ochratoxin A.
Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase
Sun, Huihua,Ho, Chun Loong,Ding, Feiqing,Soehano, Ishin,Liu, Xue-Wei,Liang, Zhao-Xun
supporting information; experimental part, p. 11924 - 11927 (2012/09/08)
Mellein and the related 3,4-dihydroisocoumarins are a family of natural products with interesting biological properties. The mechanisms of dihydroisocoumarin biosynthesis remain largely speculative today. Here we report the synthesis of mellein by a partially reducing iterative polyketide synthase (PR-PKS) as a pentaketide product. Remarkably, despite the head-to-tail homology shared with several fungal and bacterial PR-PKSs, the mellein synthase exhibits a distinct keto reduction pattern in the synthesis of the pentaketide. We present evidence to show that the ketoreductase (KR) domain alone is able to recognize and differentiate the polyketide intermediates, which provides a mechanistic explanation for the programmed keto reduction in these PR-PKSs.