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173999-18-3 Usage


suzuki reaction

Check Digit Verification of cas no

The CAS Registry Mumber 173999-18-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,9,9 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 173999-18:
193 % 10 = 3
So 173999-18-3 is a valid CAS Registry Number.

173999-18-3 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (H52891)  5-Methylpyridine-3-boronic acid, 98%   

  • 173999-18-3

  • 250mg

  • 588.0CNY

  • Detail
  • Alfa Aesar

  • (H52891)  5-Methylpyridine-3-boronic acid, 98%   

  • 173999-18-3

  • 1g

  • 1882.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name 5-Methylpyridine-3-boronic acid

1.2 Other means of identification

Product number -
Other names (5-methylpyridin-3-yl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:173999-18-3 SDS

173999-18-3Upstream product

173999-18-3Relevant articles and documents

A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction

Zhong, Linlin,Tran, Tuan,Baguley, Tyler D,Lee, Sang Jun,Henke, Adam,To, Andrew,Li, Sijia,Yu, Shan,Grieco, Fabio A,Roland, Jason,Schultz, Peter G,Eizirik, Decio L,Rogers, Nikki,Chartterjee, Arnab K,Tremblay, Matthew S,Shen, Weijun

supporting information, p. 3470 - 3485 (2018/08/03)

Background and Purpose: Beta cell apoptosis is a major feature of type 1 diabetes, and pro-inflammatory cytokines are key drivers of the deterioration of beta cell mass through induction of apoptosis. Mitochondrial stress plays a critical role in mediating apoptosis by releasing cytochrome C into the cytoplasm, directly activating caspase-9 and its downstream signalling cascade. We aimed to identify new compounds that protect beta cells from cytokine-induced activation of the intrinsic (mitochondrial) pathway of apoptosis. Experimental Approach: Diabetogenic media, composed of IL-1β, IFN-γ and high glucose, were used to induce mitochondrial stress in rat insulin-producing INS1E cells, and a high-content image-based screen of small molecule modulators of Casp9 pathway was performed. Key Results: A novel small molecule, ATV399, was identified from a high-content image-based screen for compounds that inhibit cleaved caspase-9 activation and subsequent beta cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose, which together mimic the pathogenic diabetic milieu. Through medicinal chemistry optimization, potency was markedly improved (6–30 fold), with reduced inhibitory effects on CYP3A4. Improved analogues, such as CAT639, improved beta cell viability and insulin secretion in cytokine-treated rat insulin-producing INS1E cells and primary dispersed islet cells. Mechanistically, CAT639 reduced the production of NO by allosterically inhibiting dimerization of inducible NOS (iNOS) without affecting its mRNA levels. Conclusion and Implications: Taken together, these studies demonstrate a successful phenotypic screening campaign resulting in identification of an inhibitor of iNOS dimerization that protects beta cell viability and function through modulation of mitochondrial stress induced by cytokines.

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