174006-75-8

Upstream product

• 108735-89-3 2-p-Tolyl-thiazole-4-carbaldehyde oxime 
• 132089-32-8 2-(4'-methylphenyl)-4-carbethoxythiazole 
• 55327-29-2 2-p-tolylthiazole-4-carbaldehyde 

Downstream Products

• 174006-79-2 2-(p-tolyl)thiazole-4-carbothioamide 

Relevant academic research and scientific papers

Synthesis, Characterization, and Antimicrobial Screening of 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole Derivatives

A series of novel 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole (8a-p) derivatives has been synthesized and screened for antibacterial activity against four pathogenic bacteria, Escherichia coli, Pseudomonas flurescence, Staphylococcus aureus, and Bacillus subtilis. Among them, compounds 8a and 8j exhibited excellent antibacterial activity with minimum inhibitory concentration range of 1.0 to 5.3?μg/mL and compounds 8m and 8p exhibited moderate to good antibacterial activity with minimum inhibitory concentration range of 16.9 to 29.7?μg/mL against all tested strains. All the synthesized compounds were screened for their in vitro antifungal activity against Cocinida candida. Most of the compounds reported moderate antifungal activity. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimicrobial agent.

Hantzsch reaction intermediates as a means to obtain bisthiazoles and 5-acetyl-bisthiazoles

The synthesis, chemical and spectral data of some intermediates of Hantzsch's reaction is described. The synthesis of some 4-R-5-R1-2'-Aryl-2,4'-bisthiazoles was presented too. By interaction of acetic anhydride, hydroxythiasoline derivatives were converted to 5-acetyl-bisthiazoles.