174021-63-7Relevant articles and documents
Fradcarbazole A compound and preparation method and application thereof
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Paragraph 0015, (2019/07/01)
The invention discloses a fradcarbazole A compound and a preparation method and application thereof. The fradcarbazole A compound is prepared from staurosporine or halogenated staurosporine which is subjected to a sulfur acylation reaction, a salt forming reaction together with iodomethane, a substitution reaction and a dehydrating cyclization reaction. The fradcarbazole A compound has very high selectivity and inhibitory activity on acute myeloid cell strains, namely MV4-11, with Flt3-ITD mutation, has a weak inhibiting effect on human peripheral blood mononuclear cells (PBMC), and can be developed to be an efficient and low-toxicity drug for preventing and treating leukemia.
Preparation method of 5-bromoindole derivative
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Paragraph 0027; 0028, (2017/10/23)
The invention discloses a preparation method of a 5-bromoindole derivative tert-butyl 2-(5-bromo-1H-indole-3-yl)ethyl carbamate. The preparation method comprises the following steps: taking 5-bromoindole as an initial raw material, and performing a Friedel-Craft reaction, amidation, reduction and a tert-butyloxycarbonyl protection reaction to obtain the target product. The compound is an important medical intermediate compound.
INDOLE-DERIVED ARYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE, 5HT1B AND 5HT1D RECEPTORS
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, (2008/06/13)
Novel indole-derived azylpiperazines of general formula (I), wherein, inter alia, R 1 is NH 2 or NO 2, R' 1, R 2, R' 2, R 3 and R 4 are H, Z is--C--and X is 0. Methods for preparing such derivatives and the therapeutical uses thereof are also disclosed.