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174023-48-4

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174023-48-4 Usage

Uses

Isourolithin A is an intestinal microbial metabolite of ellagitannins. It is also a potential inhibitor of 3-phosphoglycerate kinase.

Check Digit Verification of cas no

The CAS Registry Mumber 174023-48-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,0,2 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 174023-48:
(8*1)+(7*7)+(6*4)+(5*0)+(4*2)+(3*3)+(2*4)+(1*8)=114
114 % 10 = 4
So 174023-48-4 is a valid CAS Registry Number.

174023-48-4Downstream Products

174023-48-4Relevant articles and documents

Scalable Multicomponent Synthesis of (Hetero)aryl-Substituted Phenyls: Focus on Metal-Free Halogenated Biaryls, 3-Arylindoles, and Isourolithine A Synthesis

Temperini, Andrea,Lanari, Daniela,Colognese, Francesco,Piazzolla, Francesca

, p. 7711 - 7719 (2019/12/12)

In the context of the growing interest of the scientific community for the development of sustainable synthetic strategies to access aromatic structures, we present a practical and metal-free approach to (hetero)biaryls which exploits the advantages of multicomponent reactions in sustainable solvents. In situ acid-catalysed generation of (hetero)aryl acetoxy dienes from the corresponding (hetero)arylidene acetones in a metal vessel, followed by Diels-Alder reaction using an electron-poor alkyne as dienophile, delivers the expected aromatic products after final oxidation of the cycloadduct. This protocol has been demonstrated as a convenient alternative to the previously reported synthetic strategies, considering its scalability and environmental sustainability and the low cost of substrates and equipment. Moreover, it has been successfully applied to the metal-free regioselective synthesis of (hetero)aryl-substituted-phenyls, 2-unsubstituted-3-aryl-indoles, and to the total synthesis of isourolithine A.

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