174074-89-6

Basic information

• Product Name: Methyl2,4-dichloroquinazoline-7-carboxylate
• Synonyms: Methyl2,4-dichloroquinazoline-7-carboxylate
• CAS NO: 174074-89-6
• Molecular Formula: C₁₀H₆Cl₂N₂O₂
• Molecular Weight: 257.075
• Mol File: 174074-89-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 303.3 °C at 760 mmHg
• Flash Point: 137.3 °C
• Appearance: /
• Density: 1.496 g/cm³
• Refractive Index: 1.639
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.38±0.30(Predicted)
• CAS DataBase Reference: Methyl2,4-dichloroquinazoline-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2,4-dichloroquinazoline-7-carboxylate(174074-89-6)
• EPA Substance Registry System: Methyl2,4-dichloroquinazoline-7-carboxylate(174074-89-6)

Safety Data

• Hazardous Substances Data: 174074-89-6(Hazardous Substances Data)

Usage

General Description

Methyl 2,4-dichloroquinazoline-7-carboxylate is a chemical compound with the molecular formula C11H7Cl2N2O2. It is a derivative of quinazoline, a heterocyclic compound with a benzene ring fused to a pyrimidine ring. This particular compound has chlorine atoms attached to the 2 and 4 positions of the quinazoline ring and a methyl ester group attached to the 7 position of the ring. It is used in organic synthesis and medicinal chemistry, where it may be employed as a building block in the preparation of pharmaceutical compounds or other biologically active molecules. The specific properties and potential applications of methyl 2,4-dichloroquinazoline-7-carboxylate would depend on its individual characteristics and the context in which it is used.

InChI:InChI=1/C10H6Cl2N2O2/c1-16-9(15)5-2-3-6-7(4-5)13-10(12)14-8(6)11/h2-4H,1H3

Upstream product

• 5372-81-6 dimethyl aminoterephthalate 
• 174074-88-5 2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester 
• 174074-88-5 methyl 2,4-dihydroxyquinazoline-7-carboxylate 

Downstream Products

• 953039-79-7 methyl 2-chloroquinazoline-7-carboxylate 
• 1374203-86-7 4-(3-(4-(7-(2-hydroxypropan-2-yl)-4-morpholino-quinazolin-2-yl)phenyl)ureido)-N,N-dimethyl-benzamide 

Relevant articles and documents

SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES

The present application provides novel substituted quinazoline and pyrido- pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS

The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R1, X, R3, x, and ring A are as defined in the present application.