174187-07-6 Usage
General Description
6,7,8,9-Tetrahydro-dibenzofuran-4-ylamine, also known as THF-4-amine, is a chemical compound with a molecular structure consisting of a dibenzofuran ring system fused to a tetrahydrofuran ring, and an amine functional group. It is utilized in organic synthesis and pharmaceutical research as a building block for the creation of various derivatives and analogs. 6,7,8,9-TETRAHYDRO-DIBENZOFURAN-4-YLAMINE has demonstrated potential as a drug candidate for the treatment of neurological and psychiatric disorders due to its ability to modulate the activity of certain neurotransmitter receptors in the brain. Additionally, it shows promise as a ligand for the development of selective agonists and antagonists for these receptors, making it a valuable tool in medicinal chemistry and neuroscience research.
Check Digit Verification of cas no
The CAS Registry Mumber 174187-07-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,1,8 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 174187-07:
(8*1)+(7*7)+(6*4)+(5*1)+(4*8)+(3*7)+(2*0)+(1*7)=146
146 % 10 = 6
So 174187-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H13NO/c13-10-6-3-5-9-8-4-1-2-7-11(8)14-12(9)10/h3,5-6H,1-2,4,7,13H2
174187-07-6Relevant articles and documents
7-(N-substituted)amino-2,3-polymethylene benzofurane derivatives with tracheal relaxant activity
Vazzana,Sparatore
, p. 637 - 642 (2007/10/03)
A set of twelve 7-(N-substituted)amino-2,3-polymethylenebenzofuranes (1-12) together with three related compounds (13-15) was prepared. Ten selected compounds were tested for tracheal relaxant activity in vitro and two of them (6,7) were also subjected to a broad pharmacological screening. Five compounds (2, 7, 9, 12, 14) at the concentration of 30 μg/ml exhibited high tracheal relaxant activity (73-94% tone reduction) that was superior than that of theophylline at the same concentration. The 7-(N-trifluoromethylsulfonyl)amino-2,3-tetramethylenebenzofurane (9) was highly active till the concentration of 1 μg/ml giving a stronger tracheal relaxation than amrinone at 3 μg/ml. On the other hand the general screening did not show any other major activity. The benzofurane derivatives 1-13 were obtained through obvious steps from the corresponding 7-nitrobenzofuranes, which were prepared by a Fischer indole-like cyclization of O-[(2-nitro)phenyl] ketone oximes. In one case two peculiar side products were isolated.
