174191-68-5

Upstream product

• 10065-72-2 L-Alanine methyl ester 
• 95863-98-2 2-(((benzyloxy)carbonyl)amino)-3-methylbut-2-enoic acid 
• 843646-79-7 methyl N-(N-benzyloxycarbonyl-β-nitrovalyl)-L-alaninate 
• 843647-15-4 methyl ((benzyloxy)carbonyl)-C²-tosylglycyl-L-alaninate 
• 621-84-1 O-benzyl carbamate 
• 66381-10-0 ((benzyloxy)carbonyl)-C²-tosylglycine 

Relevant academic research and scientific papers

A new synthetic method for dipeptides containing α,β- didehydroamino acids utilizing an α-tosylglycine residue

The reaction of peptides containing an N-Boc- or N-Z-α-tosylglycine residue at the N-terminus with a variety of excess nitro compounds under basic conditions to give the nitro compound-adducts in good yields, followed by the elimination of nitrous acid fr

Dehydrooligopeptides. XVIII. Enzymatic hydrolysis and coupling of dehydrodipeptide esters containing α-dehydroamino acid residue by using papain

The enzymatic hydrolysis of N-protected dehydrodipeptide methyl esters (2) (Protect-ΔAA-AA-OMe) was first achieved, despite the requisite of the only neutral and large proteinic L-α-amino acid (AA) in the case using papain. Furthermore, the reverse enzymatic coupling of the C-component 2 with N-component α-amino acid anilides or dehydrodipeptide esters containing dehydrovaline (ΔVal) residue was also successful. Consequently, the present study suggests that the proteolytic enzyme papain is able to become a very useful tool for peptide synthesis by a coupling of the C-component dehydropeptide with N-component α-amino acid, peptide, or dehydropeptide.