174201-41-3

Upstream product

• 151-50-8 potassium cyanide 
• 174201-40-2 C₄₉H₇₃N₃O₇SSi₂ 
• 126771-88-8 1α,3β-bis<(tert-butyldimethylsilyl)oxy>-23,24-bisnorchol-5,7-dien-22-ol 
• 15988-11-1 4-Phenylurazole 

Downstream Products

• 174201-35-5 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)-24-norchol-6-en-23-al 
• 174201-38-8 24,24-difluoro-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholest-6-ene-1α,3β-diol 
• 174201-43-5 C₄₇H₇₅F₂N₃O₄Si₂ 

Relevant academic research and scientific papers

The first synthesis of 24,24-difluoro-1α-hydroxyvitamin D3 by means of radical deoxygenation of alcohols

The first synthesis of the title compound 4, a novel analog of 1α- hydroxyvitamin D (α-calcidiol) that might be therapeutically useful, is described. A key feature in the synthesis is the radical deoxygenation of the diol 21, which was prepared according to the previously reported procedure starting from 17. The resulting deoxygenated product 22 with the desired side-chain moiety was finally led to 4 in a conventional manner. Some aspects of the unusual reactivity of 25-OH on radical deoxygenation are also discussed.