174232-36-1

Basic information

• Product Name: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-1-methyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one
• Synonyms: Pyrrolo(4,3,2-de)quinolin-8(1H)-one, 3,4-dihydro-7-((2-(4-hydroxyphenyl)ethyl)amino)-1-methyl-; pyrrolo[4,3,2-de]quinolin-8(1H)-one, 3,4-dihydro-7-[[2-(4-hydroxyphenyl)ethyl]amino]-1-methyl-
• CAS NO: 174232-36-1
• Molecular Formula: C₁₉H₁₉N₃O₂
• Molecular Weight: 321.3731
• Mol File: 174232-36-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 568.2°C at 760 mmHg
• Flash Point: 297.4°C
• Density: 1.34g/cm³
• Vapor Pressure: 1.64E-13mmHg at 25°C
• Refractive Index: 1.694
• CAS DataBase Reference: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-1-methyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-1-methyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one(174232-36-1)
• EPA Substance Registry System: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-1-methyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one(174232-36-1)

Safety Data

• Hazardous Substances Data: 174232-36-1(Hazardous Substances Data)

Upstream product

• 51-67-2 tyrosamine 
• 160208-41-3 1,3,4,8-tetrahydro-7-methoxy-1-methyl-8-oxopyrrolo<4,3,2-de>quinoline 
• 212829-61-3 (4-Chloro-6-methoxy-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-dimethyl-amine 
• 212829-62-4 (4-chloro-6-methoxy-1-methylindol-3-yl)acetonitrile 
• 110385-66-5 (4-Chloro-6-methoxy-1H-indol-3-yl)-acetonitrile 
• 212829-63-5 4-chloro-6-methoxy-1-methyltryptamine 
• 62467-65-6 1-(6-methoxy-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 3189-13-7 6-methoxylindole 
• 60-19-5 tyramine hydrochloride 

Relevant articles and documents

Synthesis and biological evaluation of pyrroloiminoquinone derivatives

Synthesis of 10 pyrroloiminoquinone derivatives is presented. The strategy is based around the elaboration of a common intermediate by reaction with primary amines. All the compounds obtained have been subjected to antiproliferative activity with three different cell lines (NCI-H460, HeLa, and HL-60). The capacity of 4 selected compounds to affect the enzymatic activity of the nuclear enzyme DNA topoisomerase II and to form the typical DNA fragmentation which occurs in the apoptotic process is discussed here.