174283-00-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1219933-95-5 (1S,2R)-1-(benzylamino)-3-(tert-butyldimethylsilyloxy)-1-phenylpropan-2-ol 
• 165683-83-0 (2S,3S)-3-tert-butoxycarbonylamino-1-tert-butyldimethylsilyloxy-3-phenyl-2-propanol 
• 165683-81-8 (2S,3S)-3-((tert-butoxycarbonyl)amino)-3-phenyl-1,2-propanediol 
• 174282-99-6 (2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane 

Downstream Products

• 681125-79-1 (2R,3S)-3-phenyl-3-(tert-butoxycarbonylamino)-2-(1-ethoxyethoxy)propionic acid 
• 124605-42-1 methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate 

Relevant academic research and scientific papers

A stereoselective synthesis of (+)-L-733,060 from ethyl (R)-(+)-2,3-epoxypropanoate

An asymmetric synthesis of neurokinin substance P receptor antagonist (+)-L-733,060 starting from enantiomerically pure ethyl (R)-(+)-2,3-epoxypropanoate (ethyl glycidate) is described. The synthesis relies on a diastereoselective reductive amination, regioselective intramolecular epoxide opening, and in situ cyclization as the key steps.

An enantioselective, stereodivergent approach to anti- and syn-α-hydroxy-β-amino acids from anti-3-amino-1,2-diols. Synthesis of the ready for coupling Taxotere side chain

Both anti- and syn-α-hydroxy-β-amino acids are efficiently synthesised in protected form and high enantiomeric purity from readily available anti-N-Boc-1-tert-butyldimethylsilyl-3-amino-1,2-diols. The preparation of the anti series is straightforward, and