174293-30-2Relevant academic research and scientific papers
Highly regioselective ring-opening of epoxides with amines: A metal- A nd solvent-free protocol for the synthesis of β-amino alcohols
Li, Dong,Wang, Jing,Yu, Shibo,Ye, Silei,Zou, Wenjie,Zhang, Hongbin,Chen, Jingbo
supporting information, p. 2256 - 2259 (2020/03/04)
We herein report a metal- A nd solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity. Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.
A new recyclable functionalized mesoporous SBA-15 catalyst grafted with chiral Fe(iii) sites for the enantioselective aminolysis of racemic epoxides under solvent free conditions
Halder, Mita,Bhanja, Piyali,Roy, Susmita,Ghosh, Swarbhanu,Kundu, Sudipta,Islam, Md. Mominul,Islam, Sk. Manirul
, p. 97599 - 97605 (2016/10/31)
An efficient and enantioselective strategy for the catalytic ring opening of racemic meso and terminal epoxides with aromatic as well as cyclic amine derivatives has been reported over a new mesoporous SBA-15 catalyst grafted with a chiral Fe(iii) complex
Chiral Co(III)-salen complex supported over highly ordered functionalized mesoporous silica for enantioselective aminolysis of racemic epoxides
Islam, Md. Mominul,Bhanja, Piyali,Halder, Mita,Kundu, Sudipta K.,Bhaumik, Asim,Islam, Sk. Manirul
, p. 109315 - 109321 (2016/11/30)
Here we demonstrate the synthesis of a novel chiral Co(iii)-salen complex supported functionalized 2D-hexagonal mesoporous silica material Co(iii)@AFS-1. This material has shown excellent catalytic activity for the regio- and enantioselective asymmetric ring opening (ARO) of terminal and meso epoxides using various aromatic as well as cyclic amines to produce chiral β-amino alcohols having very good enantioselectivities (ee > 99%) at ambient temperature under solvent-free neat conditions.
Fe(Cp)2BF4: An efficient lewis acid catalyst for the aminolysis of epoxides
Yadav, Geeta Devi,Chauhan, Manmohan Singh,Singh, Surendra
, p. 629 - 634 (2014/03/21)
Ferrocenium tetrafluoroborate [Fe(Cp)2BF4] is an efficient Lewis acid catalyst for the aminolysis of aromatic, aliphatic, and cyclic epoxides using aniline and substituted anilines as the nucleophile to provide regioselective β-amino alcohols in 61-97% yields under solvent-free conditions at room temperature. The ring opening of cyclohexene oxide with aliphatic amines gave 2-aminocyclohexanols in 33-98% yields at 60 °C under solvent-free conditions. Georg Thieme Verlag Stuttgart New York.
