1743-01-7

Usage

Uses

Used in Scientific Research:
1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE is used as a research chemical for [application reason], contributing to the advancement of chemical and pharmaceutical sciences.
Used in Pharmaceutical Development:
1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE is used as a building block in the synthesis of pharmaceutical compounds for [application reason], facilitating the creation of new drugs and therapeutic agents.
Used in Drug Synthesis:
1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE is used as a key intermediate in the synthesis of various organic compounds for [application reason], playing a crucial role in the development of novel chemical entities with potential therapeutic applications.
Used in Medical Applications:
1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE is used as a therapeutic agent for [application reason], leveraging its potential pharmacological properties for treating specific medical conditions.
Note: The specific "application reason" for each use case would be determined by the particular context in which 1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE is being applied, such as its role in a specific synthesis process, its interaction with biological targets, or its contribution to a drug's efficacy and safety profile.

InChI:InChI=1/C10H13N.ClH/c11-10-6-5-8-3-1-2-4-9(8)7-10;/h1-4,10H,5-7,11H2;1H/p-1

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 138206-92-5 dibenzyl N-(1,2,3,4-tetrahydro-1-oxonaphthalen-2-yl)-N,N'-hydrazinedicarboxylate 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 138206-89-0 benzyl (3aRS,9bSR)-N-(2,3,3a,4,5,9b-hexahydro-2-oxonaphth<2.1-d>oxazol-3-yl)carbamate 

Downstream Products

• 101113-74-0 N-(1,2,3,4-tetrahydro-[2]naphthyl)-butyramide 
• 134865-82-0 benzoyl-(1,2,3,4-tetrahydro-[2]naphthylamine) 
• 129295-68-7 N-(1,2,3,4-tetrahydro-2-naphthyl)-2-phenylacetamide 
• 327037-25-2 5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide 
• 138006-40-3 phenylmethyl 1,2,3,4-tetrahydronaphthalene-2-carbamate 

Relevant academic research and scientific papers

Benzocycloalkylazolethione derivatives

The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine β-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.

DERIVATIVES OF 4-(AMINOMETHYL) PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Compounds of general formula (I) STR1 in which n is 1 or 2; R represents a linear or branched C 1-C 3-alkyl group; andX represents at least one substituent chosen from hydrogen, halogen, C 1-C 3-alkyl and C 1-C 3-alkoxy, in the form of a free base or an acid addition salt thereof, and their therapeutic application.

Synthesis of Amines and Amino Alcohols by Electrophilic Amination and Highly Stereoselective Reduction

A practical and selective method for the synthesis of the β-arylamines 5 and the cis- or trans-amino alcohols 8 and 11 is reported.The reaction sequence starts from α-tetralones 1 which readily react with dibenzyl azodicarboxylate to afford the protected α-hydrazino ketones 2.Then, depending on the reduction conditions, the trans-hydrazino alcohols 10 or the cis isomers 7 are formed predominantly.The stereoselectivities which range between 18:1 and 1:67 (trans/cis) are explained by stereoelectronic effects (?,?* interactions) and steric hindrance.Depending on the workup procedure, we can control, whether the cis-hydrazino alcohols 7 or the oxazolidinone derivatives 3 are isolated.Subsequent hydrogenolyses of 4, 7 and 10 lead to the target molecules 5, 8 and 11, respectively. Key Words: Electrophilic amination / Dibenzyl azodicarboxylate / Stereoselective reduction

Comparison of Biological Effects of N-Alkylated Congeners of β-Phenylethylamine Derived from 2-Aminotetralin, 2-Aminoindan, and 6-Aminobenzocycloheptene

Three series of bicyclic, semirigid congeners of β-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions.Pharmacologic activity was associated with 2-aminotetralin and 2-aminoindan derivatives, but was not found with 6-aminobenzocycloheptene derivatives.Noteworthy is the ability of several aminotetralins and aminoindans to increase the hot-plate reaction time without eliciting dopaminergic effects.This action was not blocked by pretreatment with naloxone.