1743-01-7

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE
• Synonyms: 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE;1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE;1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride;1,2,3,4-Tetrahydro-2-naphthylamine hydrochloride;2-Naphthalenamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1);2-Amino-1,2,3,4-tetrahydronaphthalenehydrochloride;2-AMino-1,2,3,4-tetrahydronaphthalene HCl;1,2,3,4-tetrahydronaphthalen-2-aMine hydrochloride
• CAS NO: 1743-01-7
• Molecular Formula: C₁₀H₁₃N*ClH
• Molecular Weight: 183.68
• EINECS: 217-111-7
• Mol File: 1743-01-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 241 °C
• Boiling Point: 250.7 °C at 760 mmHg
• Flash Point: 111.6 °C
• Appearance: /
• Density: 1.023g/cm³
• Vapor Pressure: 0.0214mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE(1743-01-7)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE(1743-01-7)

Safety Data

• Hazardous Substances Data: 1743-01-7(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-naphthalen-2-ylamine hydrochloride is a chemical compound that is commonly used in scientific research and pharmaceutical development. It is an amine derivative that is often employed as a building block in the synthesis of various organic compounds. This chemical is known for its potential pharmacological properties and has been studied for its potential therapeutic applications. Its hydrochloride salt form is commonly used for its increased solubility and stability, making it suitable for use in various experimental and medical applications. As a result, 1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride is an important chemical in the fields of chemistry, pharmacology, and drug development.

InChI:InChI=1/C10H13N.ClH/c11-10-6-5-8-3-1-2-4-9(8)7-10;/h1-4,10H,5-7,11H2;1H/p-1

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 138206-92-5 dibenzyl N-(1,2,3,4-tetrahydro-1-oxonaphthalen-2-yl)-N,N'-hydrazinedicarboxylate 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 138206-89-0 benzyl (3aRS,9bSR)-N-(2,3,3a,4,5,9b-hexahydro-2-oxonaphth<2.1-d>oxazol-3-yl)carbamate 

Downstream Products

• 101113-74-0 N-(1,2,3,4-tetrahydro-[2]naphthyl)-butyramide 
• 134865-82-0 benzoyl-(1,2,3,4-tetrahydro-[2]naphthylamine) 
• 129295-68-7 N-(1,2,3,4-tetrahydro-2-naphthyl)-2-phenylacetamide 
• 327037-25-2 5-[N-(tert-butoxycarbonyl)amino]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)salicylamide 
• 138006-40-3 phenylmethyl 1,2,3,4-tetrahydronaphthalene-2-carbamate 

Relevant articles and documents

Benzocycloalkylazolethione derivatives

The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine β-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.

Synthesis of Amines and Amino Alcohols by Electrophilic Amination and Highly Stereoselective Reduction

A practical and selective method for the synthesis of the β-arylamines 5 and the cis- or trans-amino alcohols 8 and 11 is reported.The reaction sequence starts from α-tetralones 1 which readily react with dibenzyl azodicarboxylate to afford the protected α-hydrazino ketones 2.Then, depending on the reduction conditions, the trans-hydrazino alcohols 10 or the cis isomers 7 are formed predominantly.The stereoselectivities which range between 18:1 and 1:67 (trans/cis) are explained by stereoelectronic effects (?,?* interactions) and steric hindrance.Depending on the workup procedure, we can control, whether the cis-hydrazino alcohols 7 or the oxazolidinone derivatives 3 are isolated.Subsequent hydrogenolyses of 4, 7 and 10 lead to the target molecules 5, 8 and 11, respectively. Key Words: Electrophilic amination / Dibenzyl azodicarboxylate / Stereoselective reduction