17431-55-9

Basic information

• Product Name: methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)
• CAS NO: 17431-55-9
• Molecular Formula: C₁₈H₃₄Cl₂N₂O₅S
• Molecular Weight: 461.444
• Mol File: 17431-55-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 628.1°C at 760 mmHg
• Flash Point: 333.6°C
• Vapor Pressure: 2.07E-18mmHg at 25°C
• CAS DataBase Reference: methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)(17431-55-9)
• EPA Substance Registry System: methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)(17431-55-9)

Safety Data

• Hazardous Substances Data: 17431-55-9(Hazardous Substances Data)

Upstream product

• 16684-06-3 clindamycin 
• 154-21-2 lincomycin 
• 25420-97-7 2,3,4-tris-O-(trimethylsilyl)lincomycin 
• 859-18-7 lincomycin hydrochloride 

Downstream Products

• 147650-54-2 3,4-o-isopropylideneclindamycin 
• 147650-54-2 C₂₁H₃₇ClN₂O₅S 
• 1446499-23-5 C₃₃H₅₄N₄O₁₁S₃ 

Relevant articles and documents

Preparation method of clindamycin hydrochloride impurities

The invention relates to a preparation method of clindamycin hydrochloride impurities, which belongs to the field of medicines. The technical problem to be solved by the invention is that a method forefficiently preparing clindamycin hydrochloride impurities 7-epilincomycin and 7-epilincomycin hydrochloride reference substances is lacked in the prior art. The invention provides a preparation method of a clindamycin hydrochloride impurity intermediate shown as a formula II, which comprises the following steps: by using a compound shown as a formula I and R1COOH as raw materials, carrying out aMitsunobu substitution reaction for preparation, and adding amine and/or a nitrogen-containing aromatic heterocyclic compound into a reaction solution. The invention further provides a complete synthesis method of the 7-epilincomycin and the 7-epilincomycin hydrochloride. The complete synthesis method comprises the following steps: by taking lincomycin as a raw material, carrying out silicon protection group coating, selective deprotection, Mitsunobu substitution reaction and hydrolysis reaction to obtain the 7-epilincomycin, and further carrying out a chlorination reaction to prepare the 7-epilincomycin hydrochloride.

Crystaline clindamycin free base

A processes for preparing crystalline clindamycin free base is provided.