174312-95-9

Basic information

• Product Name: 3-chloro-2,4,6-trifluorobenzoic acid
• Synonyms: 3-chloro-2,4,6-trifluorobenzoic acid
• CAS NO: 174312-95-9
• Molecular Weight: 210.54
• Mol File: 174312-95-9.mol

Chemical Properties

• CAS DataBase Reference: 3-chloro-2,4,6-trifluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2,4,6-trifluorobenzoic acid(174312-95-9)
• EPA Substance Registry System: 3-chloro-2,4,6-trifluorobenzoic acid(174312-95-9)

Safety Data

• Hazardous Substances Data: 174312-95-9(Hazardous Substances Data)

Upstream product

• 27074-08-4 5-chloro-2,4,6-trifluoroisophthalic acid 

Downstream Products

• 174312-96-0 3-chloro-2,4,6-trifluorobenzoyl chloride 
• 127625-05-2 5-Benzylamino-1-cyclopropyl-7,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 174312-98-2 ethyl 2-(3-chloro-2,4,6-trifluorobenzoyl)-3-cyclopropylacrylate 
• 174312-97-1 ethyl 3-chloro-2,4,6-trifluorobenzoylacetate 

Relevant articles and documents

Imidazo- and triazoloquinolones as antibacterial agents. Synthesis and structure-activity relationships

4,5-Disubstituted 6-cyclopropyl-6,9-dihydro-9-oxo-1H-imidazo- (30-32) and triazolo[4,5-f]quinoline-8-carboxylic acids (33-35) were synthesized starting from 5,6-diaminoquinolones 25. The imidazoquinolones 30-32 were equal or superior to the corresponding triazoloquinolone analogues 33-35 in in vitro antibacterial activity. As for the C-5 substituents, a fluorine atom was the most favorable of the three groups, H, F, and Cl. Among the compounds prepared, 4-(cyclic amino)-5-fluoro-imidazoquinolones 31a-d showed potent and well-balanced antibacterial activity against both gram-positive and gram- negative bacteria. Structure-activity relationships for the C-4 substituents (cyclic amino groups) were also examined in detail.