174320-65-1Relevant articles and documents
Synthesis of pyridopyrazino[2,3-b]indoles and 10H-indolo[3,2-g]pteridins
Bergman, Jan,Damberg, Charlotta,Vallberg, Hans
, p. 31 - 36 (2007/10/03)
The reactions between isatin (8a) and N-acetylisatin (8b) with pyridine-2,3-diamine (9a), pyridine-3,4-diamine (9b) and pyrimidine-4,5-diamine (21) were studied. 10H-Pyrido[3′,2′:5,6]pyrazino[2,3-b]indole (5a), 6H-pyrido[2′,3′:5,6]-pyrazino[2,3-b]indole (5b), 6H-pyrido[3′,4′:5,6]pyrazino[2,3-b]indole (5c) and 10H-pyrido[4′,3′:5,6]pyrazino[2,3-b]indole (5d) were regioselectively synthesized in a three-step synthesis from N-acetylisatin and the appropriate pyridine diamine. The structures of the intermediates were assigned by NOESY experiments. In the same manner, 10H-indolo[3,2-g]pteridine (24) was synthesized from N-acetylisatin and pyrimidine-4,5-diamine.