174339-89-0

Basic information

• Product Name: 5-(2-phenylethyloxy)indole
• Synonyms: 5-(2-phenylethyloxy)indole
• CAS NO: 174339-89-0
• Molecular Formula: C₁₆H₁₅NO
• Molecular Weight: 237
• Mol File: 174339-89-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-phenylethyloxy)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-phenylethyloxy)indole(174339-89-0)
• EPA Substance Registry System: 5-(2-phenylethyloxy)indole(174339-89-0)

Safety Data

• Hazardous Substances Data: 174339-89-0(Hazardous Substances Data)

Upstream product

• 1953-54-4 indol-5-ol 
• 584-08-7 potassium carbonate 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 174339-90-3 3-(2-amino-1,2-dioxoethyl)-5-(2-phenylethyloxy)indole 

Relevant articles and documents

NOVEL RHO KINASE INHIBITORS AND METHODS OF USE

The subject invention concerns materials and methods for treating diseases and disorders associated with expression of Rho associated kinases (ROCKs). Examples of diseases and disorders contemplated within the scope of the invention include, but are not limited to, oncological disorders, cardiovascular diseases, CNS disorders, and inflammatory disorders. In one embodiment, a method of the invention comprises administering a therapeutically effective amount of one or more compounds of the present invention, or a composition comprising the compounds, to a person or animal in need of treatment. The subject invention also concerns compounds that inhibit ROCKs, and compositions that comprise the inhibitor compounds of the invention. Compounds contemplated within the scope of the invention include, but are not limited to, those compounds shown in Table (5).

Binding of 5-Arylalkyloxytryptamines at Human 5-HT1Dβ Serotonin Receptors

Several 5-substituted tryptamine derivatives were prepared and examined for their binding at 5-HT1D serotonin receptors. Initially, a region of bulk tolerance was probed. Subsequently, a series of 5-(arylalkyloxy)tryptamines was prepared. Within a homolog