17434-28-5

Upstream product

• 83-33-0 inden-1-one 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 64666-42-8 1-methyl-1-indanol 

Downstream Products

• 16307-16-7 2-(4-(dimethylamino)benzyl)-2,3-dihydro-1H-inden-1-one 
• 1201647-60-0 2,4-di(4-N,N-dimethylaminophenyl)spiroindan-2',3'-inden[1,2-b]-2,4-dihydrothiapyran-1'-thione 
• 5402-87-9 C₁₈H₂₁NO 
• 16307-26-9 [4-(1H-Inden-2-ylmethyl)-phenyl]-dimethyl-amine 

Relevant academic research and scientific papers

Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network

Two-photon imaging is an emerging tool for biomedical research and clinical diagnostics. Electron donor–acceptor (D–A) type molecules are the most widely employed two-photon scaffolds. However, current D–A type fluorophores suffer from solvatochromic quenching in aqueous biological samples. To address this issue, we devised a novel class of D–A type green fluorescent protein (GFP) chromophore analogues that form a hydrogen-bond network in water to improve the two-photon efficiency. Our design results in two-photon chalcone (TPC) dyes with 0.80 quantum yield and large two-photon action cross section (210 GM) in water. This strategy to form hydrogen bonds can be generalized to design two-photon materials with anti-solvatochromic fluorescence. To demonstrate the improved in vivo imaging, we designed a sulfide probe based on TPC dyes and monitored endogenous H2S generation and scavenging in the cirrhotic rat liver for the first time.

In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones

Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening to

Evaluation of silica-H2SO4 as an efficient heterogeneous catalyst for the synthesis of chalcones

We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.

Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy

The synthesis and aromatase inhibitory activity of a new series of 2-benzylidene indanones is presented. The imidazolyl-substituted indanones displayed potent aromatase inhibitory activity. The vanilloid-based derivative 2-[4-(3-imidazol-1-ylpropoxy)-3-me

[4+2]cycloaddition reactions involving 2-arylmethylidene-1-thiooxoindan intermediates and antimicrobial activity evaluation of some products

2-(4-Fluorophenyl)methylidene-1-thiooxoindane-, 2-(4-methoxyphenyl) methylidene-1-thiooxoindane-, 2-(4-N,N-dimethyaminophenyl)methylidene-1- thiooxoindane dimers 5a-c were prepared by the reaction of the corresponding , -unsaturated ketones 3a-c with Lawe