17434-93-4Relevant academic research and scientific papers
Microwaves and Aqueous Solvents Promote the Reaction of Poorly Nucleophilic Anilines with a Zincke Salt
Zeghbib, Narimane,Thelliere, Paul,Rivard, Michael,Martens, Thierry
, p. 3256 - 3262 (2016/05/19)
The Zincke reaction allows the transformation of primary amines into their respective N-alkylated or N-arylated pyridinium salts. While nucleophilic primary amines (typically, aliphatic primary amines) often lead to quantitative reactions and has been doc
An efficient ultrasonic-assisted synthesis of imidazolium and pyridinium salts based on the Zincke reaction
Zhao, Sanhu,Xu, Xiaoming,Zheng, Lu,Liu, Hai
experimental part, p. 685 - 689 (2011/02/23)
A mild and efficient method has been developed using ultrasound irradiation for the synthesis of imidazolium and pyridinium salts based on the Zincke reaction. Tertiary nitrogen nucleophiles such as pyridines and imidazoles can be alkylated with primary amine by simply using their ammonium form Zincke salts. In almost all cases, a clear yield increase results and a dramatic reduction of the reaction time accompanied by an improved quality of the products occurs.
