174347-72-9

Basic information

• Product Name: 6-(benzo[b]furan-2-yl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine
• CAS NO: 174347-72-9
• Molecular Weight: 327.426
• Mol File: 174347-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(benzo[b]furan-2-yl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(benzo[b]furan-2-yl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine(174347-72-9)
• EPA Substance Registry System: 6-(benzo[b]furan-2-yl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine(174347-72-9)

Safety Data

• Hazardous Substances Data: 174347-72-9(Hazardous Substances Data)

Upstream product

• 23489-36-3 1-(benzofuran-2-yl)-2-bromoethan-1-one 
• 116673-95-1 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole 
• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 

Downstream Products

• 174347-73-0 [6-(2-benzofuranyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]oxoacetic acid ethyl ester 

Relevant articles and documents

Synthesis and evaluation of a novel series of pyrrolizine derivatives as dual cyclooxygenase-1 and 5-lipoxygenase inhibitors

The aim of our study was to investigate structure activity relationship following the replacement of the 6-phenyl substituent at the 6,7-diaryl-2,3-dihydropyrrolizine template by various heteroaromatic residues. In this context we developed a new, efficient, and highly sensitive test method for the screening of dual cyclooxygenase-1 (COX-1) and 5-lipoxygenase (5-LOX) inhibitors. We used human platelets as a source of COX-1 and human PMNLs as a source of 5-LOX. Both cell types were isolated from the same volume of blood. PGE2 and LTB4 respectively were determined by highly selective and sensitive ELISA kits, using monoclonal antibodies. For a single determination at most 0.5 mL whole blood is needed.