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174389-11-8

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174389-11-8 Usage

General Description

(2S,3S)-3-hydroxy-1,2-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl) ester is a chemical compound that consists of a pyrrolidine ring with two carboxylic acid groups and a hydroxyl group. The phenylmethyl ester group is attached to the hydroxyl group, adding a phenylmethyl side chain to the molecule. (2S,3S)-3-hydroxy-1,2-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl) ester is commonly used as a building block in the synthesis of peptides and pharmaceuticals due to its ability to act as a chiral source of proline, which is an amino acid used in the synthesis of proteins. It can also be used as a chiral auxiliary in asymmetric synthesis reactions. Additionally, it has potential applications in the development of new drug molecules and in the study of the structure-activity relationships of biologically active compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 174389-11-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,3,8 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 174389-11:
(8*1)+(7*7)+(6*4)+(5*3)+(4*8)+(3*9)+(2*1)+(1*1)=158
158 % 10 = 8
So 174389-11-8 is a valid CAS Registry Number.

174389-11-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,3S)-N-(benzyloxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174389-11-8 SDS

174389-11-8Upstream product

174389-11-8Relevant articles and documents

The stereochemical course of addition of allyltrimethylsilane to protected L-alaninals and L-serinals in the presence of Lewis acids. Total synthesis of cis-(2R,3S)-3-hydroxyproline

Gryko,Prokopowicz,Jurczak

, p. 1103 - 1113 (2007/10/03)

The influence of Lewis acids on the diastereoselectivity of the addition of allyltrimethylsilane to variously protected L-alaninals and L-serinals was investigated and high levels of asymmetric induction were achieved. Stereochemical models for rationalisation of the results obtained are proposed. cis-(2R,3S)-3-Hydroxyproline was synthesised starting from N-Cbz, O-TBS-L-serinal, in which the crucial step involves addition of allyltrimethylsilane to the aldehyde in the presence of SnCl4.

Highly Stereoselective Synthesis of cis-(2R,3S)-3-Hydroxyproline

Jurczak, Janusz,Prokopowicz, Piotr,Golebiowski, Adam

, p. 7107 - 7110 (2007/10/02)

Allyltrimethylsilane (5) reacted with N-carbobenzoxy-O-tert-butyldimethylsilyl-L-serinal (4) to give with high diastereoselectivity syn-adduct 3 which was subsequently transformed into cis-(2R,3S)-3-hydroxyproline (1).

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