17440-83-4 Usage
Chemical Properties
Pale yellow or greenish-yellow powder.
Uses
Different sources of media describe the Uses of 17440-83-4 differently. You can refer to the following data:
1. Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
2. Diuretic;Antialdosteron
3. An epithelial sodium channel blocker
Definition
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.
Brand name
Midamor (Merck).
Check Digit Verification of cas no
The CAS Registry Mumber 17440-83-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,4 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 17440-83:
(7*1)+(6*7)+(5*4)+(4*4)+(3*0)+(2*8)+(1*3)=104
104 % 10 = 4
So 17440-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
