174402-41-6

Upstream product

• 174402-35-8 C₄₀H₃₅N₃O₆ 
• 20289-27-4 7-benzyloxyindole 
• 3005-27-4 3,4-dibromo-1-methyl-2,5-dihydropyrrole-2,5-dione 
• 1123-61-1 3,4-dichloro-1-methyl-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Processes for the preparation of indolopyrrolocarbazole derivatives

This invention relates to processes for the preparation of intermediates which are useful in the synthesis of compounds of the general formula or pharmaceutically salts thereof, wherein R1 and R2 each represent an OH group, R1/

Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings

In the course of a study of 6-N-amino-substituted analogues of NB-506 (1), a more potent anticancer drag, J-109,404 (2), in which the formyl group of NB-506 was replaced with a 1,3-dihydroxypropane group, was reported. A study of further modification in the positions of two hydroxyl groups at the indole rings of 2 resulted in the discovery of a 2,10-dihydroxy analogue, J- 107,088 (3), which is a promising anticancer agent with a broader therapeutic window than J-109,404.