174417-14-2Relevant academic research and scientific papers
β-Acylation of ethyl pyrrole-2-carboxylate by Friedel-Crafts acylation: Scope and limitations (synthetic studies on indoles and related compounds. XXXVIII
Tani,Ariyasu,Nishiyama,Hagiwara,Watanabe,Yokoyama,Murakami
, p. 48 - 54 (2007/10/03)
The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under several conditions using various Lewis acids and acyl chlorides. The acylation with various acyl chlorides in the presence of aluminum chloride gave exclusively ethyl 4-acylpyrrole-2-carboxylate (5), whereas weaker Lewis acids such as zinc chloride and boron trifluoride etherate gave a mixture of ethyl 4- and 5-acylpyrrole-2-carboxylates.
THE FRIEDEL-CRAFTS ACYLATION OF ETHYL PYRROLE-2-CARBOXYLATE. SCOPE, LIMITATIONS, AND APPLICATION TO SYNTHESIS OF 7-SUBSTITUTED INDOLES
Murakami, Yasuoki,Tani, Masanobu,Ariyasu, Takahiro,Nishiyama, Chika,Watanabe, Toshiko,Yokoyama, Yuusaku
, p. 1855 - 1860 (2007/10/02)
The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under a variety of conditions using various Lewis acids and acyl chlorides.The acylation with some Lewis acids such as BF3*OEt2 gave a mixture of 4- and 5-acyl derivatives (5 and
