174417-54-0Relevant articles and documents
Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
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, (2008/06/13)
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS
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Page 268, (2010/02/05)
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
SYNTHESIS OF OPTICALLY ACTIVE O,O,O-TRIMETHYLKORUPENSAMINES A AND B
Rao, A. V. Rama,Gurjar, Mukund K.,Ramana, D. Venkata,Chheda, Abhay K.
, p. 1 - 6 (2007/10/02)
Hydrolysis of benzofuran derivative (10) with concomitant aromatisation produced the biaryl system (11).Subsequent Sharpless asymmetric epoxidation of the cinnamyl alcohol (13) gave atropisomers (14) and (15) conveniently separated by chromatography.Indep