174422-13-0

Basic information

• Product Name: 2-(2-Chloro-phenyl)-1H-benzimidazole-5-carboxylic acid
• Synonyms: 2-(2-Chloro-phenyl)-1H-benzimidazole-5-carboxylic acid;2-(2-chlorophenyl)-1H-1,3-benzodiazole-5-carboxylic acid
• CAS NO: 174422-13-0
• Molecular Formula: C₁₄H₉ClN₂O₂
• Molecular Weight: 272.69
• Mol File: 174422-13-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-Chloro-phenyl)-1H-benzimidazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Chloro-phenyl)-1H-benzimidazole-5-carboxylic acid(174422-13-0)
• EPA Substance Registry System: 2-(2-Chloro-phenyl)-1H-benzimidazole-5-carboxylic acid(174422-13-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 174422-13-0(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 619-05-6 3,4-diaminobenzoic acid 

Downstream Products

• 1259500-84-9 4''-O-(2-(2-chlorophenyl)-1H-benzimidazole-5-carbonyl)hydrazinecarbonylclarithromycin 

Relevant articles and documents

Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives

Novel 4″-O-benzimidazolyl clarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. These benzimidazolyl derivatives exhibited excellent activity against erythromycin-susceptible strains better than the references, and some of them showed greatly improved activity against erythromycin-resistant strains. Compounds 16 and 17, which have the terminal 2-(4-methylphenyl)benzimidazolyl and 2-(2-methoxyphenyl)benzimidazolyl groups on the C-4″ bishydrazide side chains, were the most active against erythromycin-resistant Staphylococcus pneumoniae expressing the erm gene and the mef gene. In addition, compound 17 exhibited the highest activity against erythromycin-susceptible S. pneumoniae ATCC49619 and Staphylococcus aureus ATCC25923 as well. It is worth noting that the 4″-O-(2-aryl)benzimidazolyl derivatives show higher activity against erythromycin-susceptible and erythromycin-resistant strains than the 4″-O-(2-alkyl)benzimidazolyl derivatives.