17445-27-1 Usage
Uses
Used in Pharmaceutical Research and Development:
(R)-2-[(S)-2-benzyloxycarbonylamino-4-methylsulfanylbytyrylamino]propanoic acid is used as a research compound for its potential therapeutic applications in the treatment of various diseases and conditions. Its unique structure and chiral center make it a valuable tool in drug design and molecular targeting studies, contributing to the development of novel pharmaceuticals.
Used in Drug Design:
In the field of drug design, (R)-2-[(S)-2-benzyloxycarbonylamino-4-methylsulfanylbytyrylamino]propanoic acid serves as a key component in the development of new drugs. Its specific structure allows researchers to study its interactions with biological targets, potentially leading to the creation of more effective and targeted medications.
Used in Molecular Targeting Studies:
(R)-2-[(S)-2-benzyloxycarbonylamino-4-methylsulfanylbytyrylamino]propanoic acid is utilized in molecular targeting studies to understand its interactions with specific biological molecules. This knowledge can be applied to develop drugs that can selectively target disease-causing agents, improving treatment efficacy and reducing side effects.
Used in Medicinal Chemistry:
As an important research target in medicinal chemistry, (R)-2-[(S)-2-benzyloxycarbonylamino-4-methylsulfanylbytyrylamino]propanoic acid is employed to study its chemical properties and biological activities. This research can lead to the discovery of new therapeutic agents and a deeper understanding of the underlying mechanisms of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 17445-27-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,4 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17445-27:
(7*1)+(6*7)+(5*4)+(4*4)+(3*5)+(2*2)+(1*7)=111
111 % 10 = 1
So 17445-27-1 is a valid CAS Registry Number.
17445-27-1Relevant academic research and scientific papers
The efficient preparation of di- and tripeptides by coupling N-(Cbz- or Fmoc-α-aminoacyl)benzotriazoles with unprotected amino acids
Katritzky, Alan R.,Angrish, Parul,Suzuki, Kazuyuki
, p. 411 - 424 (2007/10/03)
N-(Cbz- or Fmoc-α-aminoacyl)benzotriazoles 2 and N-protected peptidoylbenzotriazoles 6 are coupled in aqueous acetonitrile solution with free amino acids or dipeptides to prepare: (i) 22 chirally pure dipeptides 5a-v (in an average yield of 82%) from N-(Cbz- or Fmoc-α-aminoacyl)benzotriazoles 2 and unprotected amino acids, (ii) five chiral tripeptides 7a-e (in an average yield of 75%) from N-protected peptidoylbenzotriazoles 6 and unprotected amino acids, (iii) one chiral tripeptide 7g (62%) from N-(Cbz- or Fmoc-α- aminoacyl)benzotriazole 2a and the free dipeptide 8. In all, N-(Cbz- or Fmoc-α-aminoacyl)benzotriazole derivatives of 17 of the 20 naturally occurring amino acids were used, including those containing the following unprotected side chain functionalities: alcoholic -OH (Ser), indole -NH (Trp), imidazole -NH, phenolic -OH (Tyr), -CONH2 (Gln, Asn), -SH (Cys), -CO2H (Glu, Asp), and -S-S (Cystine). Support for the complete retention of chirality was obtained by parallel experiments involving D-Ala, L-Ala, and DL-Ala for the preparation of di- and tripeptides. This and other evidence for chiral integrity was supported by NMR and HPLC analyses. Georg Thieme Verlag Stuttgart.
