174464-44-9

Upstream product

• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 174464-40-5 BOC-An^oGlu ethylene dithioketal Ile-OCH₃ 
• 174464-33-6 tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-5-<2,2-(1,3-dithiolanyl)>-5-(2-methoxyphenyl)pentanoate 
• 174464-31-4 tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-5-<2,2-(1,3-dioxolanyl)>-5-(2-methoxyphenyl)pentanoate 
• 174464-38-1 (S)-2-((tert-butoxycarbonyl)amino)-5-<2,2-(1,3-dithiolanyl)>-5-(2-methoxyphenyl)pentanoic acid 

Downstream Products

• 174464-46-1 BOC-Met-An^oGlu-Ile-OCH₃ 

Relevant academic research and scientific papers

Synthesis of anisolylated aspartyl and glutamyl tripeptides

A process has been developed for transforming the β-carboxyl of aspartate and the γ-carboxyl of glutamate into anisolyl ketones. These ketones are occasional byproducts in peptide synthesis, resulting from deprotection or resin-removal processes in the presence of anisole as a scavenger. The ketone amino acids have been incorporated in a tripeptide by coupling with CBMIT. During peptide bond formation the keto group of the glutamyl residue required protection, which was provided as the ethylene dithioketal.