174472-00-5

Upstream product

• 177963-03-0 ((S)-2-Azido-1-methoxy-ethyl)-benzene 
• 3558-61-0 (S)-methyl 2-methoxy-2-phenylacetate 
• 66051-01-2 (S)-2-methoxy-2-phenylethanol 
• 61825-54-5 (S)-2-methoxy-2-phenylethylene para-toluenesulphonate 
• 500763-83-7 (S)-(+)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid benzyl ester 
• 124817-06-7 (S)-2-azido-1-phenylethanol 
• 70111-05-6 (S)-2-chloro-1-phenylethanol 
• 177963-02-9 ((S)-2-Chloro-1-phenyl-ethoxy)-trimethyl-silane 
• 752258-45-0 ((S)-2-Azido-1-phenyl-ethoxy)-trimethyl-silane 

Relevant academic research and scientific papers

Lewis acid-mediated highly regioselective SN2-type ring-opening of 2-Aryl-N-tosylazetidines and aziridines by alcohols

(Chemical Equation Presented) Lewis acid-mediated highly regioselective SN2-type ring-opening of 2-aryl-N-tosylazetidines with alcohols to afford various 1,3-amino ethers in excellent yields with good enantiomeric excess is described. Similar S

Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

The selective induction of death in cancer cells is a major challenge in modern medicine. In this communication we describe the synthesis of an 88-membered combinatorial library, and the subsequent evaluation of these compounds for their ability to selectively induce apoptosis in cancerous cells. A compound was identified from the library that induces apoptosis in U-937 and HL-60 cell lines. This compound is a remarkably selective pro-apoptotic agent for these cancer cell lines, as it does not induce significant death in noncancerous white blood cells, even at concentrations as high as 1000 μM. Copyright

Asymmetric synthesis of β-alkoxy substituted phenethylamide analogs

The enantioselective synthesis of beta-alkoxy substituted phenethylamines is described. The enantiomeric excess of the products ranges from 77 to 87%.