17448-84-9

Basic information

• Product Name: ethyl (2E)-2-(furan-2-ylmethylidene)-3-oxobutanoate
• CAS NO: 17448-84-9
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.2106
• Mol File: 17448-84-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 134.6°C
• Density: 1.159g/cm³
• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: ethyl (2E)-2-(furan-2-ylmethylidene)-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2E)-2-(furan-2-ylmethylidene)-3-oxobutanoate(17448-84-9)
• EPA Substance Registry System: ethyl (2E)-2-(furan-2-ylmethylidene)-3-oxobutanoate(17448-84-9)

Safety Data

• Hazardous Substances Data: 17448-84-9(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 280573-96-8 5-amino-7-benzylselanyl-8-cyano-4-furan-2-yl-2-methyl-1,4-dihydro-[1,6]naphthyridine-3-carboxylic acid ethyl ester 
• 1298032-96-8 ethyl 5-cyano-6-[cyano(4'-phenyl-1',3'-selenazol-2'-yl)methyl]-4-(furan-2'-yl)-2-methyl-1,4-dihydropyridine-3-carboxylate 
• 1314236-52-6 (1S,2R,3R)-ethyl 2-formyl-3-(furan-2-yl)-5-hydroxy-1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-carboxylate 
• 1352788-16-9 3-(α-furyl)-5-(2-hydroxyethyl)amino-2,4-diethoxycarbonyl-1-methyl-4-cyclohexen-1-ol 
• 1352788-17-0 3-(α-furyl)-5-(3-hydroxypropyl)amino-2,4-diethoxycarbonyl-1-methyl-4-cyclohexen-1-ol 
• 1352788-25-0 3-(α-furyl)-5-(2-hydroxyethyl)amino-2-ethoxycarbonyl-4-acetyl-1-methyl-4-cyclohexene-1-ol 
• 328236-95-9 5-amino-7-benzylseleno-8-cyano-3-ethoxycarbonyl-2-methyl-1,6-naphthyridine 

Relevant articles and documents

Asymmetric Synthesis of Pentasubstituted Cyclohexanes through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction

An asymmetric domino Michael/Michael reaction of α,β-unsaturated aldehydes 1 and α-acetyl-β-substituted-α,β-unsaturated esters 2 catalyzed by diphenylprolinol silyl ether was developed. This is a formal carbo [4+2] cycloaddition reaction affording penta-s

Enzyme catalytic promiscuity: The papain-catalyzed Knoevenagel reaction

Papain as a sustainable and inexpensive biocatalyst was used for the first time to catalyze the Knoevenagel reactions in DMSO/water. A wide range of aromatic, hetero-aromatic and α,β-unsaturated aldehydes could react with less active methylene compounds acetylacetone and ethyl acetoacetate. The products were obtained in moderate to excellent yields with Z/E selectivities of up to 100:0. This case of biocatalytic promiscuity not only widens the application of papain to new chemical transformations, but also could be developed into a potentially valuable method for organic synthesis.

A facile synthesis of trisubstituted alkenes from β-diketones and aldehydes with AlCl3 as catalyst

Preparation of trisubstituted alkenes from low-activity β-diketones and aldehydes with aluminum chloride as catalyst has been studied. The frequently used catalyst AlCl3 is used for the first time to promote this condensation. The procedure is a convenient, low toxicity, and highly efficient method for industrial synthesis of trisubstituted alkenes in high yield. Springer Science+Business Media B.V. 2011.