174484-96-9

Upstream product

• 108-98-5 thiophenol 
• 174484-95-8 3-[(3-bromomethyl-phenyl)-cyclopropyl-methyl]-4-hydroxy-5,6,7,8,9,10-hexahydro-cycloocta[b]pyran-2-one 
• 174484-94-7 3-[cyclopropyl-(3-hydroxymethyl-phenyl)-methyl]-4-hydroxy-5,6,7,8,9,10-hexahydro-cycloocta[b]pyran-2-one 
• 174484-93-6 [3-(Cyclopropyl-hydroxymethyl)-phenyl]-methanol 
• 100058-82-0 5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on 

Relevant academic research and scientific papers

PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1

Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors

The sulfonamide substituted pyranones (I) have recently been shown to be potent HIV protease inhibitors. We prepared a series of sulfone substituted analogs and compared their biological activities to those of the corresponding sulfonamide analogs. It was determined that although these compounds maintained activity as enzyme inhibitors, they showed somewhat diminished antiviral activity even though they may possess increased membrane permeability.