174504-73-5

Basic information

• Product Name: ethyl 3,6-dibromo-7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate
• CAS NO: 174504-73-5
• Molecular Weight: 365.021
• Mol File: 174504-73-5.mol

Chemical Properties

• CAS DataBase Reference: ethyl 3,6-dibromo-7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,6-dibromo-7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate(174504-73-5)
• EPA Substance Registry System: ethyl 3,6-dibromo-7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate(174504-73-5)

Safety Data

• Hazardous Substances Data: 174504-73-5(Hazardous Substances Data)

Upstream product

• 174504-72-4 ethyl 3-bromo-7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 119647-72-2 4-[5-(ethoxycarbonyl)-1H-pyrrol-3-yl]butanoic Acid 
• 119647-73-3 ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate 
• 119647-71-1 4-[5-(ethoxycarbonyl)-1H-pyrrol-3-yl]-4-oxobutanoic acid 
• 174504-68-8 ethyl 4-(3-methoxycarbonylpropionyl)pyrrole-2-carboxylate 
• 174504-69-9 ethyl 4-(3-methoxycarbonylpropyl)pyrrole-2-carboxylate 

Relevant articles and documents

New strategy for indole synthesis from ethyl pyrrole-2-carboxylate (synthetic studies on indoles and related compounds. XXXIX)

As a synthetic application of the previously reported C4-acylation of ethyl pyrrole-2-carboxylate (1), a new strategy for indole synthesis was developed. Ethyl pyrrole-2-carboxylate (1) was allowed to react with succinic anhydride or 3-methoxycarbonylpropionyl chloride to give, in good yield, a C4-succinyl derivative of 1, which was converted into ethyl 7-oxo-4,5,6,7- tetrahydroindole-2-carboxylate (6) as a key intermediate for indole synthesis. Starting from 6, several indoles functionalized on the benzene moiety were synthesized.