174506-63-9

Basic information

• Product Name: 2,5-Morpholinedione, 6-methyl-4-[(1S)-1-phenylethyl]-, (6R)-
• CAS NO: 174506-63-9
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Mol File: 174506-63-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,5-Morpholinedione, 6-methyl-4-[(1S)-1-phenylethyl]-, (6R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Morpholinedione, 6-methyl-4-[(1S)-1-phenylethyl]-, (6R)-(174506-63-9)
• EPA Substance Registry System: 2,5-Morpholinedione, 6-methyl-4-[(1S)-1-phenylethyl]-, (6R)-(174506-63-9)

Safety Data

• Hazardous Substances Data: 174506-63-9(Hazardous Substances Data)

Downstream Products

• 936845-15-7 (3S,6R)-3-(4'-benzyloxy-(2'E)-butenyl)-6-methyl-4-[(S)-phenethyl]-morpholine-2,5-dione 
• 177186-31-1 (Z)-(S)-6-Benzyloxy-2-((S)-1-phenyl-ethylamino)-hex-4-enoic acid amide 
• 176966-58-8 (3S,5S)-5-Iodomethyl-3-((S)-1-phenyl-ethylamino)-dihydro-furan-2-one 
• 177186-30-0 (S)-2-((S)-1-Phenyl-ethylamino)-pent-4-enoic acid amide 
• 177186-28-6 (3S,6R,1'S)-4-(1'-phenylethyl)-3-(2-propen-1-yl)-6-methyl-1,4-morpholin-2,5-dione 
• 936845-16-8 3-(3-benzyloxymethyl-oxiranylmethyl)-6-methyl-4-(1-phenyl-ethyl)-morpholine-2,5-dione 
• 936845-18-0 (3S,6R,2'R,3'R)-3-(4'-benzyloxy-2',3'-dihydroxybutyl)-6-methyl-4-[(S)-phenethyl]-morpholine-2,5-dione 
• 177186-29-7 (3S,6R)-3-(4'-benzyloxy-(2'Z)-butenyl)-6-methyl-4-[(S)-phenethyl]-morpholine-2,5-dione 

Relevant articles and documents

Enantioselective Synthesis of (R)- and (S)-α-Aminoacids using (6S)- and (6R)-6-Methyl-morpholine-2,5-dione Derivatives

The alkylation of both 3 and 4 gives exclusively the trans derivatives 5 and 6, respectively, with >98% diastereoselectivity. Cleavage of the morpholine-2,5-dione ring of 5 and 6 leads to enantiomerically pure (S)- and (R)-α-aminoacids, respectively. The configurations of stereogenic centers introduced on 3, 4, 5 and 6 have been assigned on the basis of the 1H-NMR data, conformational analysis and nOe measurements.