174510-86-2

Upstream product

• 72155-45-4 Boc-L-phenylalaninal 
• 219586-42-2 2-<2(S)-(tert-Butoxyformamido)-1-hydroxy-3-phenylpropyl>thiazole 
• 219586-44-4 2-<(4S,5S)-4-benzyl-3-tert-butoxycarbonyl-2,2-dimethyl-1,3-oxazolidin-5-yl>-1,3-thiazole 

Downstream Products

• 187818-07-1 (2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-diphenyl-4N,3O-isopropylidene-3-pentanol 
• 187818-09-3 (4S,5S)-5-((S)-1-Amino-2-phenyl-ethyl)-4-benzyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 129822-17-9 (2S,4S)-2,4-diamino-1,5-diphenyl-3-hydroxypentane 
• 187818-10-6 (2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-diphenyl-4N,3O-isopropylidene-3-pentanol 
• 187818-11-7 (4S,5R)-5-((R)-1-Amino-2-phenyl-ethyl)-4-benzyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 187818-12-8 (Z)-N-<(4S,5S)-4-benzyl-3-tert-butoxycarbonyl-2,2-dimethyl-5-methylenyl-1,3-oxazolidinyl>benzylamine N-oxide 
• 187818-12-8 C₂₅H₃₂N₂O₄ 

Relevant academic research and scientific papers

A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease

Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2, and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease. Copyright

Grignard addition to aldonitrones. Stereochemical aspects and application to the synthesis of C2-symmetric diamino alcohols and diamino diols

A new example of the stereoselective installation of the amino group at a saturated carbon center via organometallic addition of chiral aldehydes to nitrones is illustrated by the synthesis of 1,3-diamino propanol 1 and 1,4- diamino butandiol 2 units. Three diamino alcohol 1 stereotriads were obtained by stereoselective addition of alkylmagnesium halides (benzyl, cyclohexylmethyl, and metallyl) to the N-benzyl nitrones derived from β- amino-α-hydroxy aldehydes followed by reduction of the resulting N- benzylhydroxylamines. Three 1,4-dibenzyl substituted stereoisomers of type 2 with fixed S configuration at C2 and C3 were prepared by sequential and simultaneous amination in two directions starting from L-threose nitrone and L-tartraldehyde bis-nitrone, respectively. The R,S,S,R isomer obtained by the former route was converted into a seven-membered ring cyclic urea (1,3- diazapin-2-one), i.e., a compound that belongs to a class of nonpeptide HIV- 1 protease inhibitors.