174522-59-9

Upstream product

• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 69383-41-1 methyl 2-(4-(4-chlorophenoxy)phenyl)acetate 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 1415596-12-1 C₃₂H₂₈ClNO₂S 
• 1415596-14-3 C₂₅H₂₂ClNO₂S 
• 1415596-30-3 C₃₂H₃₇ClN₂O₂S 
• 1415596-28-9 C₃₃H₃₇ClN₂O₂S 
• 1415596-70-1 C₁₈H₁₉ClO₂ 
• 1415596-71-2 C₁₈H₁₈Cl₂O₂ 
• 1415596-69-8 C₁₆H₁₆ClNO₃ 
• 180302-69-6 5-(4-(4-chlorophenoxy)-phenylacetylamino)-3-ethyl-1-methylpyrazole 
• 137619-30-8 {2-[4-(4-Chloro-phenoxy)-phenyl]-1-[(Z)-hydroxyimino]-ethyl}-phosphonic acid diethyl ester 
• 137619-47-7 {1-Amino-2-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-phosphonic acid diethyl ester 
• 137619-72-8 {1-Amino-2-[4-(4-chloro-phenoxy)-phenyl]-ethyl}-phosphonic acid 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease

A series of thiazole derivatives were designed, and prepared to develop RAGE antagonist for the treatment of Alzheimer's disease (AD). SAR studies were performed to optimize inhibitory activity on Aβ-RAGE binding. SAR studies showed that introducing an amino group at part A was essential for inhibitory activity on Aβ-RAGE binding. Compounds selected from Aβ-RAGE binding screening displayed inhibitory activity on Aβ transport across BBB. They also showed inhibitory activity against Aβ-induced NF-κB activation. These results indicated that our derivatives had a potential as therapeutic agent for the treatment of AD.

Acylated 5-aminopyrazoles and the use thereof to combat animal parasites

The present invention relates to new acylated 5-aminopyrazoles of the formula (I) STR1 in which R1, R2, R3, R4 and R5 have the meaning given in the description, to processes for their preparation and to their use as pesticides.