174522-87-3

Upstream product

• 174522-86-2 6-Methyl-2-methylthio-8-(3,5-di-O-p-toluoyl-2-deoxy-β-D-ribofuranosyl)-pteridine-4, 7-dione 
• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 205185-12-2 2,2-Dimethyl-propionic acid 6-methyl-2-methylsulfanyl-7-oxo-7,8-dihydro-pteridin-4-yl ester 
• 174522-85-1 (2-Methylsulfanyl-4,7-dioxo-3,4,7,8-tetrahydro-pteridin-6-yl)-acetic acid ethyl ester 
• 138612-37-0 6-methyl-2-methylthio-4(3H),7(8H)-pteridinedione 
• 54030-57-8 5,6-diamino-2-(methylthio)pyrimidin-4(3H)-one 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 174522-86-2 6-methyl-2-methylthio-8-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-4(3H),7(8H)-pteridinedione 

Downstream Products

• 174522-88-4 8-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-6-methyl-2-methylsulfonyl-4-[2-(4-nitrophenyl)ethoxy]-8H-pteridin-7-one 
• 174522-91-9 2-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-4-[2-(4-nitro-phenyl)-ethoxy]-8H-pteridin-7-one 
• 174522-89-5 8-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-6-methyl-O⁴-[2-(4-nitrophenyl)ethyl]-isoxanthopterin 
• 174522-90-8 2-Amino-8-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-methyl-4-[2-(4-nitro-phenyl)-ethoxy]-8H-pteridin-7-one 

Relevant academic research and scientific papers

Nucleosides LXII synthesis of 6-methyl-8-(2-deoxy-β-D-ribofuranosyl)- isoxanthopterin and derivatives

The syntheses of 6-methyl-8-(2-deoxy-β-D-ribofuranosyl)isoxanthopterin (21) and its protected 3'-O-phosphoramidite 23 were achieved from 6-methyl- 2-methylthio-8-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-3H,8H- pteridine-4,7-dione (8) in several steps. The new building block for oligonucleotide syntheses is highly fluorescent and can be considered as a substitute for 2'-deoxyguanosine.

Pteridine nucleotide analogs as fluorescent DNA probes

The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.