174523-25-2Relevant academic research and scientific papers
A versatile approach to the synthesis of oligonucleotide analogs containing neutral 5′-thioformacetal internucleoside linkages
Ducharme, Yves,Harrison, Kimberly A.
, p. 1410 - 1418 (2007/10/03)
Activation of nucleoside donors 5 by sulfuryl chloride followed by the addition of 5′-thionucleoside acceptors 3 yields 5′-thioformacetal dinucleotide analogs 6 with in situ trapping of liberated methanesulfenyl chloride with cyclohexene. Purine as well a
An alternative approach towards the synthesis of (3'→5') methylene acetal linked dinucleosides
Quaedflieg,Timmers,Kal,Van Der Marel,Kuyl-Yeheskiely,Van Boom
, p. 3081 - 3084 (2007/10/02)
Condensation of 5'-O-levulinoyl-3'-O-benzoyloxymethylthymidine or 5'-O-benzoyl-3'-O-acetyloxymethylthymidine with appropriately protected thymidine, d-cytidine or d-guanosine acceptors 5a-c, using trimethylsilyl trifluoromethanesulfonate (TMSOTf) as the a
