174534-38-4Relevant academic research and scientific papers
T-type Ca2+ channel blockers suppress the growth of human cancer cells
Heo, Jae Ho,Seo, Han Na,Choe, Yun Jeong,Kim, Sujin,Oh, Chun Rim,Kim, Young Deuk,Rhim, Hyewhon,Choo, Dong Joon,Kim, Jungahn,Lee, Jae Yeol
, p. 3899 - 3901 (2008)
In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment.
