174537-81-6

Basic information

• Product Name: N^α-Fmoc-4-O-[O',O''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine
• Synonyms: N^α-Fmoc-4-O-[O',O''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine
• CAS NO: 174537-81-6
• Molecular Weight: 635.686
• Mol File: 174537-81-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N^α-Fmoc-4-O-[O',O''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-Fmoc-4-O-[O',O''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine(174537-81-6)
• EPA Substance Registry System: N^α-Fmoc-4-O-[O',O''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine(174537-81-6)

Safety Data

• Hazardous Substances Data: 174537-81-6(Hazardous Substances Data)

Upstream product

• 168135-78-2 methyl N^α-Fmoc-4-O-tyrosinate 
• 168135-77-1 N^α-Fmoc-O'-(O'',O''-di-tert-butyl-2-malonyl)tyrosine 
• 174537-86-1 2-{4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-2-fluoro-malonic acid di-tert-butyl ester 

Relevant articles and documents

A one-step synthesis of Nα-Fmoc-4-O-[O′,O″-di- tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine from commercially available starting material

A one-step high yield synthesis from commercially available starting material is reported for the novel phosphotyrosyl mimetic, Nα- Fmoc-4-O-[O′,O″-di-tert-butyl-2-(2-fluoromalonyl)]-l-tyrosine. The conditions employed for this transformation may also be applicable for the direct electrophilic fluorination of other Nα-Fmoc-protected amino acids.