174562-82-4

Upstream product

• 501-53-1 benzyl chloroformate 
• 174562-83-5 (R)-2-Benzyloxycarbonylamino-3-methyl-3-methylsulfanyl-butyric acid 
• 100217-05-8 S-methyl-L-penicillamine 
• 1113-41-3 L-penicillamine 

Downstream Products

• 200114-20-1 [(R)-1-((S)-1-{(2R,3S)-3-[2-(Ethyl-isopropyl-sulfamoyl)-ethyl]-oxiranyl}-2-phenyl-ethylcarbamoyl)-2-methanesulfonyl-2-methyl-propyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

β-Methanesulfonyl-L-valine as a novel, unnatural amino acid surrogate for P2 in the design of HIV protease inhibitors

β-Methanesulfonyl-L-valine as a surrogate for asparagine and valine was designed, synthesized, and characterized. A representative compound 1 showed IC50 of 4.9 nM.

Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof

Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: wherein A, B, R1 to R4 and n have the same meanings as defined in the specification. The novel HIV protease inhibitor