174563-89-4Relevant academic research and scientific papers
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers
Zhang, Yang-Ming,Ding, Yu,Tang, Wei,Luo, Wei,Gu, Min,Lu, Wei,Tang, Jie,Zuo, Jian-Ping,Nan, Fa-Jun
experimental part, p. 9212 - 9216 (2009/04/11)
DZ2002 and its related stereoisomers were efficiently synthesized. The optical data of (R)- and (S)-DZ2002 were disclosed here for the first time. Their inhibitory potency was evaluated on SAHase and MLR assay in the mean time. In accordance with respecti
Design and synthesis of novel metalloproteinase inhibitors
Nakatani, Shingo,Ikura, Masahiro,Yamamoto, Shingo,Nishita, Yoshitaka,Itadani, Satoshi,Habashita, Hiromu,Sugiura, Tsuneyuki,Ogawa, Koji,Ohno, Hiroyuki,Takahashi, Kanji,Nakai, Hisao,Toda, Masaaki
, p. 5402 - 5422 (2007/10/03)
A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starting materials. As such, chemical modification was carried out using commercially available starting materials such as 4-aminobutyric acid, (+)- and (-)-malic acid, and d- and l-glutamic acid derivatives. Among the compounds tested, N-[4-(benzofuran-2-yl)benzoyl] 4-amino-4S-hydroxymethylbutyric acid hydroxamates derived from l-glutamic acid demonstrated more potent inhibitory activity against MMP-2 and MMP-9 compared with the corresponding 2S-hydroxy analogs or 3S-hydroxy analogs, respectively, which were derived from (-)-malic acid. Structure-activity relationship study is presented.
Optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids and pharmaceutical use thereof
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, (2008/06/13)
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of pla
