174585-86-5

Upstream product

• 26059-40-5 2-(2-iodophenyl)ethan-1-ol 
• 7789-60-8 phosphorus tribromide 
• 18698-96-9 o-iodophenylacetic acid 
• 5339-85-5 2-aminophenethyl alcohol 

Downstream Products

• 111373-35-4 2-[2-(2-Iodo-phenyl)-ethyl]-indan-1,3-dione 
• 115860-21-4 diethyl 2-(2-iodophenethyl)malonate 
• 1394351-31-5 (S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline 
• 1394351-81-5 C₁₈H₁₈I₂O₂ 
• 1394351-03-1 1,5-bis(2-iodophenyl)pentan-3-amine 
• 1394351-80-4 C₂₃H₂₆I₂O₄ 

Relevant academic research and scientific papers

Indium(III)-catalyzed one-pot synthesis of alkyl cyanides from carboxylic Acids

The one-pot preparation of alkyl cyanides from carboxylic acids via alkyl iodides or alkyl bromides, which were in situ generated either by indium(III)-catalyzed reductive iodination or bromination of carboxylic acids, is described. Georg Thieme Verlag Stuttgart New York.

Indium-catalyzed reductive bromination of carboxylic acids leading to alkyl bromides

The combination of 1,1,3,3-tetramethyldisiloxane (TMDS) and trimethylbromosilane (Me3SiBr) with a catalytic amount of indium bromide (InBr3) undertook direct bromination of carboxylic acids, which produced the corresponding alkyl bromides in good to excellent yields. The reducing system was tolerant to several functional groups.

Synthesis, radiosynthesis and preliminary in vivo evaluation of [ 123I]-(4-fluorophenyl) {1-[2-(2-iodophenyl)ethyl]piperidin-4-yl} methanone, a potential 5-HT2A-antagonist for SPECT brain imaging

Many people suffer from psychiatric illnesses like depression and anorexia. Relevant to these diseases is amongst others a malfunctioning of brain 5-HT2A-receptors. To allow in vivo quantification of these receptors with Single Photon Emission

Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2a ligands for PET or SPECT brain imaging

A series of 4′-substituted phenyl-4-piperidinylmethanol and benzoyl-4-piperidine derivatives was synthesized as potential novel serotonin 5-HT2A receptor ligands that can be radiolabeled for in vivo brain imaging. Compounds were prepared by alk

SUBSTITUTED CYCLOALKANECARBOXYLIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula STR1 wherein each T is a substituent g roup; x is 0, 1, or 2; the group D represents STR2 the subscript "e" is 2 or 3; the group R 14 represents a variety of possible substituent groups of the cycloalkyl ring between D and G; the subscript "k" is 0-2; and the group G represents M, STR3 in which M represents--CO 2 H,--CON(R 11) 2, or--CO 2 R 12 ; and R 13 represents any of the side chains of the 19 noncyclic occurring amino acids. "

A short method for the synthesis of spirocyclic diketone related to Fredericamycin-A

A new and short route for 2-(2′-bromoethyl)-1-iodobenzene, a useful intermediate for the conversion into spirocyclic diketone 9, related to Fredericamycin-A, is reported.