174602-85-8

Upstream product

• 102523-58-0 N-t-Boc-L-Phe-L-Phe(N^α-Me)-OH 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 174602-83-6 (S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionic acid benzyl ester 
• 174602-84-7 (S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester 

Downstream Products

• 182205-73-8 C₇₄H₁₁₀N₈O₁₄ 
• 182205-74-9 C₇₄H₁₁₀N₈O₁₄ 
• 182205-79-4 C₇₂H₁₀₈N₈O₁₄ 
• 127785-64-2 aureobasidin A 

Relevant academic research and scientific papers

Anti-fungal agents

Compounds of the formula STR1 or pharmaceutically acceptable salts thereof wherein R1, R2, X1, X2, X3, X4, X5, X6, X7, and X8, are as set forth herein are described. These compounds are useful as agents in the treatment of fungal infections.

Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A

A novel cyclic depsinonapeptide antifungal 1a (Sch 57697) and its isomer 1b were synthesized by a fragment coupling approach and this methodology was applied to the total synthesis of the natural product aureobasidin A. Synthetic strategies for coupling of N-methyl amino acids with minimal racemization are discussed. Biological evaluation of isomers 1a and 1b demonstrated the importance of chirality at the β-hydroxy-N-methylvaline (OHMeVal) position.