174671-50-2

Basic information

• Product Name: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL
• Synonyms: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL;2-Hydroxymethyl-5-(trifluoromethyl)phenylboronic acid
• CAS NO: 174671-50-2
• Molecular Formula: C8H6BF3O2
• Molecular Weight: 201.94
• Mol File: 174671-50-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL(174671-50-2)
• EPA Substance Registry System: 5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL(174671-50-2)

Safety Data

• Hazardous Substances Data: 174671-50-2(Hazardous Substances Data)

Usage

Description

5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL is a boronic acid derivative with the molecular formula C7H5BF3O2. It features a benzene ring with a trifluoromethyl group attached, providing unique reactivity and structural properties that make it a valuable tool in organic chemistry.

Uses

Used in Organic Synthesis:
5-(TRIFLUOROMETHYL)BENZO[C][1,2]OXABOROL-1(3H)-OL is used as a reagent for forming carbon-carbon and carbon-heteroatom bonds in organic synthesis. Its unique structure allows it to participate in various reactions, such as Suzuki-Miyaura cross-coupling and Sonogashira coupling, to create a wide range of biologically active molecules and functional materials. This makes it a versatile component in the development of pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 959687-85-5 1-bromo-2-(dimethoxymethyl)-4-(trifluoromethyl)benzene 
• 102684-91-3 2-bromo-5-(trifluoromethyl)benzaldehyde 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 
• 905710-73-8 2-bromo-5-trifluoromethyl-1-(methoxymethoxymethyl)benzene 

Relevant articles and documents

Synthesis, structure, properties and antimicrobial activity of para trifluoromethyl phenylboronic derivatives

The [2-formyl-4-(trifluoromethyl)phenyl]boronic acid as well as its benzoxaborole and bis(benzoxaborole) derivatives were obtained and their properties studied. The 2-formyl compound displays an unusual structure in the crystalline state, with a significa

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.