174681-89-1

Basic information

• Product Name: 2-Pyridinecarboxylic acid, 3-phenyl-, methyl ester
• CAS NO: 174681-89-1
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol File: 174681-89-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxylic acid, 3-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylic acid, 3-phenyl-, methyl ester(174681-89-1)
• EPA Substance Registry System: 2-Pyridinecarboxylic acid, 3-phenyl-, methyl ester(174681-89-1)

Safety Data

• Hazardous Substances Data: 174681-89-1(Hazardous Substances Data)

Upstream product

• 2459-07-6 methyl pyridine-2-carboxylate 
• 98-80-6 phenylboronic acid 
• 62733-99-7 methyl 3-hydroxypicolinate 
• 53636-56-9 methyl 3-bromopicolinate 
• 157865-84-4 methyl 3-(trifluoromethylsulfonyloxy)-pyridine-2-carboxylate 

Downstream Products

• 206181-88-6 2-(hydroxymethyl)-3-phenylpyridine 
• 57955-12-1 indeno[2,1-b]pyridin-9-one 
• 1026646-41-2 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide 
• 103863-15-6 3-phenylpyridine-2-carboxylic acid 

Relevant articles and documents

Tuning Reactivity in Pd-catalysed C(sp3)-H Arylations via Directing Group Modifications and Solvent Selection

The palladium-catalysed sp3 C?H arylation of a selection of saturated amine scaffolds was investigated using substituted picolinamide directing groups. On the bornylamine scaffold, highly selective monoarylation takes place using unsubstituted picolinamide or 3-methylpicolinamide, whereas a double C?H arylation occurs with other substituents present, becoming a significant product with 3-trifluoromethylpicolinamide. DFT calculations were used to help rationalise the effect of directing groups on the C?H palladation steps which were found experimentally to be irreversible. The substituted picolinamide directing groups were also examined on acyclic amine scaffolds and in many cases increased yields and selectivity could be obtained using methylpicolinamides. For a selection of other amine scaffolds, the yield of C?H arylation could be improved significantly using 3-methylpicolinamide as the directing group and/or 3-methylpentan-3-ol as the solvent. (Figure presented.).

Scope and limitation for FeSO4-mediated direct arylation of heteroarenes with arylboronic acids and its synthetic applications

FeSO4-mediated direct arylation of heteroarenes with arylboronic acids in the presence of K2S2O8 has been developed. A slow addition of an aqueous solution of an iron complex was crucial in the arylation. Scope and limitation of the heteroarenes and arylboronic acids are discussed. Furthermore, the direct arylation was applied to the formal total synthesis botryllazine B and sodium channel inhibitor.

OXIME COMPOUNDS AND THE USE THEREOF

The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CRsu